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Conversely, kidney dysfunction, in the context of chronic kidney disease (CKD), precipitates an expedited ageing trajectory in individuals, leading to premature ageing and a disconnect between biological and chronological age

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The fact that prolong Hp infection and accompanying atrophic gastritis results in the decrease in the number of the Gr cells that is paralleled by the decrease in plasma levels of pepsinogen I, which is considered as biomarker of the integrity of the oxyntic mucosa, suggests that Hp may indeed interfere directly with the Gr-cells and ghrelin release but this requires further studies (59)

Di Cesare Mannelli L, Ghelardini C, Toscano A, Pacini A, Bartolini A (2010) The neuropathy-protective agent acetyl-L-carnitine activates protein kinase C-gamma and MAPKs in a rat model of neuropathic pain